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RS 42358-197

CAS No. 135729-55-4

RS 42358-197 ( RS42358-197; RS-42358-197; RS 25259-007 )

产品货号. M27323 CAS No. 135729-55-4

RS 42358-197 is the S-isomer of RS-42358, which is the novel 5-HT3 receptor antagonist.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥3426 有现货
5MG ¥5273 有现货
10MG ¥7906 有现货
25MG ¥11745 有现货
50MG ¥15876 有现货
100MG ¥21303 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    RS 42358-197
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    RS 42358-197 is the S-isomer of RS-42358, which is the novel 5-HT3 receptor antagonist.
  • 产品描述
    RS 42358-197 is the S-isomer of RS-42358, which is the novel 5-HT3 receptor antagonist.(In Vitro):RS 42358-197 acts against 5-HT-induced contractions in the guinea pig ileum (low-potency phase), yielding a pA2 estimate of 8.1.(In Vivo):In anesthetized rats. RS 42358-197, administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 micrograms/kg; i.v., 5.7 micrograms/kg; i.d., and 11.6 micrograms/chamber, respectively). In this regard, when administered intraduodenally, RS 42358-197 was more potent and exhibited a longer duration of action than either ondansetron or granisetron. In dogs, RS 42358-197, administered either intravenously or orally, dose-dependently inhibited the emesis induced by cisplatin, actinomycin and cyclophosphamide, but not that induced by apomorphine. When tested at maximally effective doses against cisplatin-induced emesis in dogs, RS 42358-197 had a longer duration of antiemetic activity (> 6 h) than ondansetron (2 h). RS 42358-197, administered orally, also afforded protection against cisplatin-induced emesis in ferrets. At doses that showed marked anti-emetic activity in dogs (10-100 micrograms/kg; i.v. and 100-1000 micrograms/kg; i.d.), RS 42358-197 did not produce any hemodynamic changes.
  • 同义词
    RS42358-197; RS-42358-197; RS 25259-007
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Antifection;Platelet aggregation
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    135729-55-4
  • 分子量
    330.9
  • 分子式
    C19H23ClN2O
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    Cl.O=c1n(cc2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Sun Y, et al. In vitro Antiviral Activity of Rubia cordifolia Aerial Part Extract against Rotavirus. Front Pharmacol. 2016 Sep 13;7:308.
产品手册
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