RS 42358-197
CAS No. 135729-55-4
RS 42358-197 ( RS42358-197; RS-42358-197; RS 25259-007 )
产品货号. M27323 CAS No. 135729-55-4
RS 42358-197 is the S-isomer of RS-42358, which is the novel 5-HT3 receptor antagonist.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥3426 | 有现货 |
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5MG | ¥5273 | 有现货 |
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10MG | ¥7906 | 有现货 |
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25MG | ¥11745 | 有现货 |
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50MG | ¥15876 | 有现货 |
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100MG | ¥21303 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称RS 42358-197
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述RS 42358-197 is the S-isomer of RS-42358, which is the novel 5-HT3 receptor antagonist.
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产品描述RS 42358-197 is the S-isomer of RS-42358, which is the novel 5-HT3 receptor antagonist.(In Vitro):RS 42358-197 acts against 5-HT-induced contractions in the guinea pig ileum (low-potency phase), yielding a pA2 estimate of 8.1.(In Vivo):In anesthetized rats. RS 42358-197, administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 micrograms/kg; i.v., 5.7 micrograms/kg; i.d., and 11.6 micrograms/chamber, respectively). In this regard, when administered intraduodenally, RS 42358-197 was more potent and exhibited a longer duration of action than either ondansetron or granisetron. In dogs, RS 42358-197, administered either intravenously or orally, dose-dependently inhibited the emesis induced by cisplatin, actinomycin and cyclophosphamide, but not that induced by apomorphine. When tested at maximally effective doses against cisplatin-induced emesis in dogs, RS 42358-197 had a longer duration of antiemetic activity (> 6 h) than ondansetron (2 h). RS 42358-197, administered orally, also afforded protection against cisplatin-induced emesis in ferrets. At doses that showed marked anti-emetic activity in dogs (10-100 micrograms/kg; i.v. and 100-1000 micrograms/kg; i.d.), RS 42358-197 did not produce any hemodynamic changes.
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同义词RS42358-197; RS-42358-197; RS 25259-007
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通路Others
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靶点Other Targets
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受体Antifection;Platelet aggregation
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研究领域——
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适应症——
化学信息
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CAS Number135729-55-4
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分子量330.9
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分子式C19H23ClN2O
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.O=c1n(cc2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Sun Y, et al. In vitro Antiviral Activity of Rubia cordifolia Aerial Part Extract against Rotavirus. Front Pharmacol. 2016 Sep 13;7:308.
产品手册
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